Famous Therapeutic Levels

0.5 – 2.0 ng/mL

Toxic if > 2

#1 sign of toxicity = diarrhea

Other symptoms: n/v, visual  disturbances (yellow halos),  confusion, ataxia, and 

palpitations

Hypokalemia potentiates digoxin Toxicity.

Antidote = Digibind or Digifab

0.8-1.2 mEq/L

Toxic > 1.5

Toxicity potentiated by HYPONATREMIA

Toxicity: Early Tremors and N/V and diarrhea.  Also, Nystagmus, slurred speech, and seizures

5 – 10 mg/dL

High levels: Ototoxic (Tinnitus/hearing loss)

10 – 20 mcg/mL

Toxicity: nystagmus, hypotension, CNS depression

10 – 20 mcg/mL

Toxicity: Tachycardia, n/v, hyperglycemia

10 – 30 mcg/mL . Some sources use 10-40

Toxicity: Hypotension, CNS depression.

100- 300 mcg/mL

Toxicity: Ototoxic, hyperventilation, n/v

4 – 7 mg/dL

Toxicity: hypotension, CNS depression, depressed DTRs, decreased respiratory rate. 

10 – 20 mcg/mL

Toxicity: n/v, diarrhea, all the way to liver damage.

Peak 20 – 40 mcg/mL

Through 5 -15 mcg/mL

Nephrotoxicity: Watch urine output, potassium, BUN, and creatinine.

Red man syndrome can happen when given too fast. It typically consists of pruritus, an erythematous rash that involves the face, neck, and upper torso

50 – 100 mcg/mL

Toxicity: CNS depression, coma, respiratory depression