DKA vs HHNS

Diabetic Ketoacidosis

Patho

Low insulin prevents glucose from entering cells. The body metabolizes protein and fat into energy, leading to ketosis & acidosis

Causes

Stress, surgery, steroids, non-compliance, sepsis, & skipping insulin doses

Treatment

Hydration #1. Regular Insulin drip. Correct electrolyte imbalances and acidosis. Insulin drives K+ into the cell, so watch for hypokalemia. Regular insulin is the ONLY insulin given IV

Dehydration

From polyuria

↑ Glucose Level

Pancreas produces less insulin. Less insulin to move glucose into the cell

Acidosis & Ketosis

Metabolic Acidosis

Kussmaul Respirations

Fast breathing to blow off acid. Lungs are trying to compensate for metabolic acidosis

Hyperosmolar Hyperglycemic Non-Ketotic Syndrome

Patho

No acidosis and no ketones, but very high blood sugar

Causes

Stress, surgery, steroids, non-compliance, sepsis, & skipping insulin doses

Treatment

Hydration #1. Insulin drip. Correct electrolyte imbalances and acidosis. Insulin drives K+ into the cell, so watch for hypokalemia. Regular insulin is the ONLY insulin given IV

Dehydration

↑ serum osmolality; hypernatremia, no ketones

↑ Glucose Level

Can be as high as 600+

No acidosis

No ketones

Neuro Changes

↓ LOC

Hydration #1 Priority & Insulin
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